Orochem Technologies Inc. has developed novel SMB process to separate and purify various proteins (for example heme & RuBisCO) from plants and yeast extracts. Our technology combined ion exchange chromatographic separation with SMB technologies. Orochem’s large particle size ion-exchange resin allows high flow rate at low column pressure, perfect for commercial scale production. Protein purification SMB system includes multiple separation zones operated in parallel, thus this process is high mass transfer coefficient, high capacity, high yield and cost effective. Currently, our process has been tested for pilot scale with both yield and purity above 75%.