Protein Crash Plate and Protein Precipitation

Protein precipitation is a common protocol for rapid sample clean-up and extraction of pharmaceuticals from blood samples (whole blood, plasma and serum) during drug discovery. It also allows the disruption of drug binding to proteins. Blood samples from various species such as dogs, rats, mice, and humans show variations in their compositions, but often only a single bioanalytical method covers all these species. Protein precipitation denatures the protein and destroys its drug binding ability, depending on the binding mechanism.

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