Montelukast

Montelukast is a leukotriene receptor antagonist and an inhibitor of leukotriene biosynthesis. Montelukast sodium is used in the treatment of asthma.

Orochem Technologies Inc developed a continuous SMB process for the purification of a crude Montelukast sodium mixture comprising Montelukast sodium-trans, impurities, an organic solvent, and water. The final montelukast sodium-trans product has a montelukast purity of at least 99.5 wt-%.

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TitleCitationCutomer Affiliation
Rotary valve apparatus for simulated moving bed separationsOroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013.Orochem Technologies, Inc.
Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation systemOroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014.Orochem Technologies, Inc.
Purification of montelukast using simulated moving bed A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. OroskarOrochem Technologies, Inc.
Mannose production from palm kernel meal using simulated moving bed separationAnil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012Orochem Technologies, Inc.
SMB process for the purification of ethanol and butanediol with integrated regenerationSharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013Orochem Technologies, Inc.
Recovery of highly pure alpha-tocotrienol from crude palm oil extract Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012Orochem Technologies, Inc.