Chiral Separation of s-Valsartan from racemic mixture using Chiral SMB Technology

Valsartan (Angiotan or Diovan) is an angiotensin II receptor antagonist. Valsartan dilates blood vessels and reduces blood pressure. In the US, valsartan is indicated for treatment of high blood pressure, congestive heart failure(CHF), or post-myocardial infarction. In 2005, Angiotan was prescribed more than 12 million times in the United States and global sales were approximately $6.1 billion in 2010.

Traditional purification method involves a numerous purification step i.e. stage wise crystallization in ethyl acetate from a crude which has 95% S-Valsartan and 5 % R-Valsartan with about 50% loss of S-Valsartan in the mother liquor. ChiroSEP SMB system is being commercialized by Orochem Technologies Inc, to obtain high purity s-Valsartan crystals at production scale of 100kg /Day based upon CSP-1C chiral stationary phase developed by Orochem Technologies Inc.

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Title Citation Cutomer Affiliation
Rotary valve apparatus for simulated moving bed separations Oroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013. Orochem Technologies, Inc.
Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system Oroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014. Orochem Technologies, Inc.
Purification of montelukast using simulated moving bed A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. Oroskar Orochem Technologies, Inc.
Mannose production from palm kernel meal using simulated moving bed separation Anil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012 Orochem Technologies, Inc.
SMB process for the purification of ethanol and butanediol with integrated regeneration Sharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013 Orochem Technologies, Inc.
Recovery of highly pure alpha-tocotrienol from crude palm oil extract Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012 Orochem Technologies, Inc.