Oligonucleotides

SYNTHESIS AND ANALYSIS

Custom Oligo Synthesis Services

  • DNA and RNA
  • DNA-RNA hybrid
  • HPLC quality
  • CONFIRMATION OF OLIGO STRUCTURE BY MS
  • PURITY BY HPLC AND IE
  • Nano moles to micro moles scale

Options for Oligo Modifications

  • Backbone modification
  • Chimeric molecules – combination of DNA, RNA, LNA, 2’-OMe, and 2’Fluoro
  • Amino, Thio and Biotin spacers
  • Labeled probes (FAM, HEX, TET, ROX, Cy-3, Cy-5, etc.)
Our laboratory is equipped with synthesizers from nano moles to micro moles scale. Combined with strong analytical expertise enables us to complete any modification in oligo synthesis providing confirmation of the structure by MS and a certificate of purity for each molecule (HPLC-RP, IE).
High-throughput

Oligo Synthesis Plates

  • Custom CPG dispensing
  • 96-well and 384-well

PLEASE FILL UP THE REQUEST FORM FOR
OLIGO SYNTHESIS SERVICES BELOW

FILL THE FORM

Appendix: Letter Based Codes

BaseID 2-Letter Verbose Code
A dA dA
C dC dC
G dG dG
T dT T
a rA rA
c rC rC
g rG rG
U rU U
t 3T idT
1 mA r2’OMeA
2 mC r2’OMeC
3 mG r2’OMeG
4 mU 2’OMeU
5 As dA-s
6 Cs dC-s
7 Gs dG-s
8 Ts T-s
  1s r2’OMeA-s
J 2s r2’OMeC-s
K 3s r2’OMeG-s
L 4s 2’OMeU-s
B as rA-s
E cs rC-s
F gs rG-s
H us U-s
n 6n AminoC6
i Tn T-C6amino
b bb BiotinC6
p pp Phos
u rU U
s ss C6-SS-C6-
m n3 C7-amino-3′
h al 5′-Aldehyde 4FB
O BT Biotin-TEG
S 18 Spacer18
f FA C6FAM
r TA TAMRA
P HP HydroxyProline
M fA r2’FluoroA
N fC r2’FluoroC
Q fG r2’FluoroG
R fU 2’FluoroU
I dI dInosine
o Pn C6Amino
q Bp BiotinPEG
V n5 5’Amino5
v Bs Biotin-Osu
W TS T(S2)
X XX XXX
Y Cy Cy3
Z sT dT(thiol)
d dB Biotin
e 3S C3-Thiol
j 8g (8oxo_rg)
k gg glyceryl
l NT NHS-Carboxy-dT
w dN N
x Ch Cholesterol
y 5B Biotin-C4-amide-C4
z C5 Cy5
9 fI 2fluoro_dI

Orochem offers customized tools from
synthesis to purification

  • From lab scale to prep scale
  • Both Orochem brand or white label products

Orochem 96-Well Synthesis Plates

  • 0.7 mL and 2 mL/well
  • 7-, 10-, and 20- micron frits
  • Available empty plate for customer choice of solid supports
  • Available pre-packed with ZARA CPG

Orochem 96-Well Oroflex Filter Plates

  • 0.7 mL and 2 mL/well
  • 7-, 10-, and 20- micron frits

ZARA Oligo Deprotection Kit

  • Rapid process for the cleavage, deprotection and recovery
  • Perform at room temperature under organic condition
  • Reduce the process time to 2 hours
  • Easily automated

Phosphoramidites

for nucleic acid synthesis
DNA amidites, such as dA-N-Bz CEP,
dC-N-Ac CEP, dG-N-Ac CEP
and T-CEP

Formats:

0.5, 1, 5, 10 g, and custom packing

HPLC and UHPLC columns

Orochem’s high quality Orosil Gold and
Reliasil C18, C8, 300A and 100A columns.

EZPRESS positive pressure processors

Formats:

96-well plate
48 cartridges

Oligo Synthesis Services

  • DNA, RNA, DHA-RNA hybrid
  • Available desalted, OPC or HPLC-RP purification

QUIKVAP evaporators

Formats:

Single and double 96-well plate formats

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OLIGONUCLEOTIDE File size: 11.8MB Download
Oligo Purification Kits File size: 1.93 MB Download