Alpha- and delta-tocotrienols


Alpha tocotrienol is a natural antioxidant and it protects glutamate-induced death of neuronal cells (Brain Cells). It is a member of Vitamin E family with 4 different isomers of trienols (alpha, beta, gamma, and delta) and 4 different isomers of pherols (alpha, beta, gamma, and delta). Orochem has been successful in separating pure alpha- Tocotrienol from a crude palm oil extract feed using SMB technology. Methods of purification of component of alpha- tocotrienolfrom palm oil have been disclosed in literature, but such methods comprise either separating all the isomers of tocotrienols from the remaining tocopherols or using a complex series of reactions to convert other forms of trienols to the alpha form. Such methods have not proved to be economical for commercial scale production.

The Orpheus absorbent was used for this separation, which is a custom, modified Normal phase absorbent from Orochem Technologies. This Orpheus absorbent with SMB technology has resulted in efficient method of producing alpha-tocotrienol in pure form from palm oil extract with minimum processing steps and at low cost. Moreover, the process is useful in providing a continuous route and a simplified processing route to providing pure alpha-tocotrienol as a major product essentially free of other tocotrienols and tocopherols including: beta-tocopherol, gamma-tocotrienol, delta-tocotrienol, gamma- tocopherols, delta-tocopherols, front end and back end carotenoids, and alpha-tocopherol as a buy-product from palm oil extract.


Recently, more research results indicate that delta-tocotrienol has the most antioxidant potentials, and has been shown to reduce cholesterol and inhibit certain cancers. Using the Orpheus adsorbent with SMB technology, Orochem has the process to purify high purity delta-tocotrienol from palm oil extract.

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Title Citation Cutomer Affiliation
Rotary valve apparatus for simulated moving bed separations Oroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013. Orochem Technologies, Inc.
Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system Oroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014. Orochem Technologies, Inc.
Purification of montelukast using simulated moving bed A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. Oroskar Orochem Technologies, Inc.
Mannose production from palm kernel meal using simulated moving bed separation Anil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012 Orochem Technologies, Inc.
SMB process for the purification of ethanol and butanediol with integrated regeneration Sharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013 Orochem Technologies, Inc.
Recovery of highly pure alpha-tocotrienol from crude palm oil extract Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012 Orochem Technologies, Inc.