Montelukast is a leukotriene receptor antagonist and an inhibitor of leukotriene biosynthesis. Montelukast sodium is used in the treatment of asthma.
Orochem Technologies Inc developed a continuous SMB process for the purification of a crude Montelukast sodium mixture comprising Montelukast sodium-trans, impurities, an organic solvent, and water. The final montelukast sodium-trans product has a montelukast purity of at least 99.5 wt-%.
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|Rotary valve apparatus for simulated moving bed separations||Oroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013.||Orochem Technologies, Inc.|
|Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system||Oroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014.||Orochem Technologies, Inc.|
|Purification of montelukast using simulated moving bed||A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. Oroskar||Orochem Technologies, Inc.|
|Mannose production from palm kernel meal using simulated moving bed separation||Anil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012||Orochem Technologies, Inc.|
|SMB process for the purification of ethanol and butanediol with integrated regeneration||Sharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013||Orochem Technologies, Inc.|
|Recovery of highly pure alpha-tocotrienol from crude palm oil extract||Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012||Orochem Technologies, Inc.|