Symphony Chrome Simulated Moving Bed Chromatography Systems

The Swan F Series Simulated Moving Bed Systems

The Swan F series SMB System (Figure 1) is an automated continuous liquid chromatography system designed for preparative-scale purification of chemical compounds. The Swan F series systems are a way to run SMB on a benchtop.

Figure 1: A lab scale Symphony Chrome
SMB system

More Details
Features

  • Four different systems to meet different flow rate and output requirements
  • Plug-and-Play systems including a pump module, control module with software, chromatography
    module, powered USB hub, 8-position adjustable column stand for holding various size columns,
  • Other Accessories, like Water Bath, automatic Pump controller, and Inline detectors can be
    seamlessly attached to the system to get better productivity.
  • Various empty columns sizes with different types of materials available to meet different separation
    requirement. All sizes, designed and manufactured by Orochem Technologies Inc.
  • The columns are pre-packed with different stationary phase (either spherical or irregular)
    manufactured by Orochem Technologies Inc., to meet the process requirement.
  • Optional method development services for conversion of single column data to continuous
    chromatography parameters on request
  • Up to 90% cost reduction in resin and solvents/buffers
The Swan
The KingFisher
The Heron / The Concord
Figure 2: Throughputs for different SMB Scales, Lab and Pilot

The Swan F10

The Swan F10 system is the smallest lab scale system offered by Orochem. The Swan F10 system is
designed to be used on a benchtop with a variety of small sized columns for lab scale applications.

  • Pneumatic valve
  • 8 Column Configuration
  • Flow rates up to 12 ml/min
  • Maximum Pressure 300 psi
  • Benchtop Unit – Lab Scale
  • Approximate Throughput 1 kg per week

The Swan F100

The Swan F100 system is designed for a small footprint to be used on a benchtop with a variety of medium sized columns for lab scale applications.

  • Pneumatic valve
  • 8 Column Configuration
  • Flow rates up to 100 ml/min
  • Maximum Pressure 300 psi
  • Benchtop Unit – Lab Scale
  • Approximate Throughput 1 kg per week
  • Column Sizes 20-200 mL

The Swan F300

The Swan F300 system is designed for a small footprint to be used on a benchtop with a variety of medium sized columns for lab scale applications.

  • Pneumatic valve
  • 8 Column Configuration
  • Flow rates up to 300 ml/min
  • Maximum Pressure 300 psi
  • Benchtop Unit – Lab Scale
  • Approximate Throughput 1 kg per day
  • Column Sizes 100-1200 mL
System Selection Guide - Lab Scale
The Swan F10The Swan F100The Swan F300
Max. Flow Rate12 mL/min100 mL/min300 mL/min
Column Volume1-50 mL19-220 mL114-1235 mL
Number of Columns888
Column MaterialPPStainless Steel, Glass,Jacketed GlassStainless Steel, Glass,Jacketed Glass, CPVC,PP
Max Allowable Pressure300 psi300 psi300 psi
# of System Inlets444
# of System Outlets444
Valve TypePneumaticPneumaticPneumatic
In-line DetectorUV-VIS (optional)UV-VIS (optional)UV-VIS (optional)
Approx. Production1 kg/month1 kg/week1 kg/day
Primary UsePharmaceuticalPharmaceutical, NutraceuticalPharmaceutical, Nutraceutical, Food, Industrial

Note: Products in The Swan series are sold exclusively for separation and purification of molecules having a molecular weight less than 5,000 Da, not including oligonucleotides and peptides

The KingFisher C Series System

The KingFisher C Series system is designed for a small footprint to be used on a benchtop with a variety of medium to large sized columns for pilot scale. Offered are two different variants of The KingFisher C series, one which has the same 8 column configuration as all of the other Chrome Prep systems, and one which has a 16 column configuration for larger projects.

  • Pneumatic valve
  • 8 or 16 Column Configurations
  • Flow rates up to 3 L/min
  • Approximate Throughput 5 or 10 kg per day (I or II)
  • Tabletop Unit – Pilot Scale
  • Maximum Pressure 300 psi
  • Column Sizes 4-39 L
  • Class 1/Div1 rated (with N2 purge)

The Heron C Series System

The Heron C series system is designed to be a pilot or commercial scale step up from The Swan F series. The Heron C series feature a rotary valve type and larger line sizes which can accommodate larger column sizes and higher throughput demands.

The Heron C080

The Heron C080 system is a larger system designed for pilot scale applications.

  • Rotary valve
  • 15 Column Configuration
  • Flow rates up to 3 L/min
  • Maximum Pressure 100 psi
  • Floor mounted Pilot unit
  • Approximate Throughput 10 kg per day
  • Column Sizes 4 - 39 L
  • Class 1/Div1 rated
  • Sanitary Design available

The Heron C016

The Heron C016 system is a larger system designed for pilot scale applications.

  • Rotary valve
  • 15 Column Configuration
  • Flow rates up to 30 L/min
  • Maximum Pressure 100 psi
  • Floor mounted Pilot unit
  • Approximate Throughput 100 kg per day
  • Column Sizes 29 - 118 L
  • Class 1/Div1 rated
  • Sanitary Design

Figure 3: The Heron C016

System Selection Guide - Pilot Scale
The KingFisher C080The KingFisher C016The Heron C080The Heron C016
Max. Flow Rate3 L/min3 L/min3 L/min30 L/min
Column Volume4.1-39.5 L4.1-39.5 L4.1-39.5 L29.6-118.5 L
Number of Columns8161515
Column MaterialStainless SteelStainless SteelStainless SteelStainless Steel
Max Allowable Pressure300 psi300 psi100 psi100 psi
# of System Inlets481515
# of System Outlets481515
Valve TypePneumaticPneumaticRotaryRotary
In-line DetectorUV-VIS, Ph, & ConductivityUV-VIS, Ph, & ConductivityUV-VIS, Ph, & ConductivityUV-VIS, Ph, & Conductivity
Approx. Production5 kg/day10 kg/day10 kg/day100 kg/day
Primary UsePharmaceutical, Nutraceutical, Food, IndustrialPharmaceutical, Nutraceutical, Food, IndustrialPharmaceutical, Nutraceutical, Food, IndustrialNutraceutical, Food, Industrial

The Concord T Series Systems

The Concord T series are custom designed SMB systems for commercial scale purifications. They are two different variants based on input capacity. The Concord T1000 is design for up to 1000 ton per annual, while The Concord T1500 is for up to 1500 ton per annual.

Symphony Chrome Pump

The Symphony Chrome Pump (Figure 4) is designed for use with the The Swan F and The KingFisher C Systems. The specifications for each type of pump are listed in Table 3. High-quality materials and rugged design make this pump a reliable performer over years of service.

ModuleMinimum Flowrate (mL/min)Maximum Flowrate (mL/min)Flowrate Increments (mL/min)
The Swan F100120.01
The Swan F10001000.1
The Swan F30003000.1

Table 2: Symphony Chrome Pump specificationsTable 2: Symphony Chrome Pump specifications

Figure 4: Symphony Chrome Pump

Features

  • Dual self-flushing pump heads with overlapping cams for reduced pulsation
  • Integrated pulse dampener Real-time pressure monitoring with upper/lower pressure limits
  • Motor stall detector
  • Prime/purge valve
  • Prime button toggles flow rate to maximum for rapid solvent change
  • Inlet and outlet ruby ball/sapphire seat check valves
  • Tactile response, chemically resistant front panel keypad with LED display
  • RS-232 serial and USB communication ports

Online UV-VIS Detector

The Symphony Chrome UV-VIS DCTR Detector (Figure 5) is engineered for seamless integration with Symphony Chrome SMB Systems.

Figure 5: The Symphony Chrome UV-VIS
DCTR Detector

Features

  • Diode array design
  • Dual light sources
  • Flow rates up to 500 ml/mi
  • LED display with touch pad for optional local control
  • Simultaneous detection of up to 4 different wavelengths from 190 to 840 nm
  • Preparative flow cells in PEEK and stainless steel from 0.3 to 2.4 mm path length
  • Controlled by Symphony Chrome Screen software; capable of displaying output of two detectors in
    one window

Available Columns and Stationary Phases

Orochem provides a variety of different column sizes for all the Symphony Chrome SMB units. Columns can be sold filled with Orochem’s stationary phases, or empty so that they can be filled separately. Column sizes are listed in Table 3. Contact us for more options.
Orochem synthesizes and manufactures achiral and chiral stationary phases. For achiral phases, Orochem provides both silica based and polymer base, normal phases, reversed phases and ion- exchange phases. Orochem’s stationary phases are listed in Table 4. Contact us for more options.

Column Selection Guide
ModuleMaterial of ConstructionSizeColumn Volume
The Swan 10PolypropyleneCartridge 4 g10 mL
PolypropyleneCartridge 12 g25 mL
PolypropyleneCartridge 24 g50 mL
The Swan F100Stainless Steel10x250 mm19 mL
Stainless Steel22x300 mm114 mL
Glass15x300 mm53 mL
Glass25x450 mm220 mL
Jacketed Glass15x300 mm53 mL
Jacketed Glass25x450 mm220 mL
The Swan F300CPVC1x18 in231 mL
CPVC2x24 in1235 mL
Polypropylene1x18 in231 mL
Polypropylene2x24 in1235 mL
Stainless Steel22x300 mm114 mL
Stainless Steel50x300 mm589 mL
Stainless Steel2x24 in1235 mL
Glass24x450 mm220 mL
Glass50x600 mm1180 mL
Jacketed Glass25x450 mm220 mL
Jacketed Glass50x600 mm1180 mL
The KingFisher C080 / The KingFisher C016Stainless Steel3x36 in4.1 L
Stainless Steel4x36 in7.4 L
Stainless Steel6x36 in16.6 L
Stainless Steel8x48 in39.5 L
The Heron C080Stainless Steel8x36 in29.6 L
Stainless Steel16x36 in118.5 L

Table 3: Available columns to be used with Symphony Chrome SMB systems. More column sizes available upon request.

Available Media
Media NameCatalog NumberParticle Size (µm)
SphericalIrregular
Orpheus C18ORC1870-20040-63
Orpheus SilicaORSI70-20040-63
Orpheus Amino (NH2)ORNH270-20040-63
Orpheus Alumina A (Acidic)ORALA70-20040-63
Orpheus Alumina B (Basic)ORALB70-20040-63
Orpheus Alumina N (Neutral)ORALN70-20040-63
Orpheus FlorisilORFL70-20040-63
Orpheus CarbonORCRN/A50-80

Table 4: Available Stationary Phases for packed columns. More options available upon request.

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