Total Solution for Nutraceutical Purification and Production on Large Scale.
Orochem Technologies Inc. has successfully commercialized purification and production of nutraceuticals such as Rubisco from Spinach and Alpha-Alpha, Recombinant Heme from yeast and Proteins from Peas, DHA and EPA from fish oil, tocotrienols from palm oil, phospholipids from krill oil, specialty sugars (tagatose, stevioside, and rebauside A), curcuminoids, and xanthins (astaxanthin, zeaxanthin, and beta-cryptoxanthin) from plants, fruits, and seafood. Orochem’s R&D Center in Naperville, Illinois provides vertically integrated Chromatography and Simulated Moving Bed (SMB) process from discovery to manufacturing. Orochem’s SMB Technology for purification of EPA and DHA from Fish Oil has been commercialized since 2009 and has played a major role in development of high purity Omega-3 for Pharmaceutical and Food applications. Orochem inventors have been granted several US and European patents for this novel technology. Orochem’s team of chemists and chemical engineers assist customers to develop and implement economical and scalable process with very short cycle time.
Alpha- and delta-tocotrienols (1)
Alpha- and delta-tocotrienols
Alpha-tocotrienolAlpha tocotrienol is a natural antioxidant and it protects glutamate-induced death of neuronal cells (Brain Cells). It is a member of Vitamin E family with 4 different isomers of trienols (alpha, beta, gamma, and delta) and 4 different isomers of pherols (alpha, beta, gamma, and delta). Orochem has been successful in separating pure alpha- Tocotrienol from a crude palm oil extract feed using SMB technology. Methods of purification of component of alpha- tocotrienolfrom palm oil have been disclosed in literature, but such methods comprise either separating all the isomers of tocotrienols from the remaining tocopherols or using a complex series of reactions to convert other forms of trienols to the alpha form. Such methods have not proved to be economical for commercial scale production. The Orpheus absorbent was used for this separation, which is a custom, modified Normal phase absorbent from Orochem Technologies. This Orpheus absorbent with SMB technology has resulted in efficient method of producing alpha-tocotrienol in pure form from palm oil extract with minimum processing steps and at low cost. Moreover, the process is useful in providing a continuous route and a simplified processing route to providing pure alpha-tocotrienol as a major product essentially free of other tocotrienols and tocopherols including: beta-tocopherol, gamma-tocotrienol, delta-tocotrienol, gamma- tocopherols, delta-tocopherols, front end and back end carotenoids, and alpha-tocopherol as a buy-product from palm oil extract.
Delta-tocotrienolRecently, more research results indicate that delta-tocotrienol has the most antioxidant potentials, and has been shown to reduce cholesterol and inhibit certain cancers. Using the Orpheus adsorbent with SMB technology, Orochem has the process to purify high purity delta-tocotrienol from palm oil extract.
CurcuminoidsOrochem Technologies Inc. has developed novel SMB process to separate and purify curcuminoids from turmeric oleoresin. Our technology combined a novel chemical extraction system with SMB technologies for continuous purification of curcuminoids on large scales. The SMB system consist of columns with large particle size resin that allows high flow rate at low column pressure assembled in either parallel or series mode. The purity of curcuminoids produced by our technology is more than 95%. Additionally, Orochem Technologies has developed an SMB process for isolation and purification of mixture of the three curcuminoids which also allows for separate enrichment of any of the three at a desired concentration.
Omega 3 fatty acids (EPA and DHA) (1)
Omega 3 fatty acids (EPA and DHA)Omega 3 fatty acids are polyunsaturated fatty acids commonly found in marine and plant oils. These are considered essential fatty acids which are required by the human body but cannot synthesize them. Past research has proven that these fatty acids play an important role in brain functioning along with the normal growth and development of the human body. It is also widely believed that they may reduce the risk of heart disease. In recent years, the global demand for Omega-3 fatty acids is growing at more than 10% per annum. For many years these were only considered as dietary supplements but are now being widely used in nutraceutical and pharmaceutical grade manufacturing. The SMB (Simulated Moving Bed) technology that Orochem has developed serves the purification needs of these fatty acids in different compositions. We have proved that we are able to purify up to 97-99% by composition of Eicosapentaenoic Acid (EPA, 20 carbons and 5 double bonds), Docosahexaenoic Acid (DHA, 22 carbons and 6 double bonds) and Alpha-linolenic Acid (ALA, 18 carbon and 3 double bonds) using our custom engineered absorbent from different feed stocks commonly available in the market having lower percentages of EPA and DHA (<20%). These purified streams can now be blended in required proportions as per the client requirements.
CarotenoidsAlpha-Carotene is highly lipophilic, strongly colored red-orange pigment abundant in plants and fruits. Orochem technologies has developed an SMB process for purification of beta-Carotene from natural sources such as palm oil and paprika. Our unique technology allows manufacture of highest purity beta-Carotene from palm oil where it is present at concentration of ~350 ppm along with ~200 ppm of alpha-Carotene or from paprika (~700 ppm in dry matter).
|Protein Trend Flyer||File size: 6MB||Download|
|Purification Using Orochem's Proprietary||File size: 11MB||Download|
|SMB Chromatography Systems Pilot Scale to Industrial Scale||File size: 7.15MB||Download|
|Rotary valve apparatus for simulated moving bed separations||Oroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013.||Orochem Technologies, Inc.|
|Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system||Oroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014.||Orochem Technologies, Inc.|
|Purification of montelukast using simulated moving bed||A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. Oroskar||Orochem Technologies, Inc.|
|Mannose production from palm kernel meal using simulated moving bed separation||Anil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012||Orochem Technologies, Inc.|
|SMB process for the purification of ethanol and butanediol with integrated regeneration||Sharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013||Orochem Technologies, Inc.|
|Recovery of highly pure alpha-tocotrienol from crude palm oil extract||Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012||Orochem Technologies, Inc.|