Flash Chromatography Columns
What is Flash Chromatography?
Flash chromatography is a preparative technique for compound purification that uses pre-packed flash columns and pressurized solvent delivery for quick, efficient separations. It is commonly used in R&D, method development, and post synthesis purification to isolate compounds faster than traditional column chromatography setups.
Orochem uses symmetrical sorbent compression technology to enhance chromatographic performance, yielding sharper peaks, higher resolution, and more consistent results, especially under high-flow and large-scale chromatography conditions.
Flash Columns
Orochem Technologies manufactures flash chromatography columns designed for fast, reliable chromatography purification. From routine compound isolation to gram-scale purification workflows, our pre-packed flash columns deliver consistent separations with high reproducibility.
Flash Chromatography Phases & Specifications
We offer a full range of phases for flash chromatography columns in:
- Normal phase (NP)
- Reversed phase (RP)
- Ion exchange (IX)
Phases include:
- Silica (irregular or spherical)
- N-Alumina, A-Alumina, B-Alumina
- C18, NH2, CN, Diol, SCX, SAX
Specifications:
- Particle sizes: 40–63 µm (irregular) or 10 & 50 µm (spherical)
- Pore size: 60 Å
EZY FLASH Columns (Luer-Lock Connections)
Orochem’s EZYFLASH Cartridges are a novel product conveniently equipped with Luer-Lock connections, compatible with most flash chromatography systems.
Features
- Machine packed with ultra-high purity silica gel using a proprietary dry packing technique
- Luer-Lock connections
- Compatible with most flash chromatography systems
- Liquid sample injection (sample loader)
- Narrow particle size distribution and low trace metal content sorbent
- Max pressure: up to 300 psi for normal phases; up to 400 psi for reversed phases
- Available chemistries: Silica, Diol, CN, NH2, Phenyl, Phenyl-Hexyl, C8, C18, C18-AQ, SAX, SCX, Alumina (A / B / N)
- Size range: 4g, 12g, 25g, 40g, 80g, 120g, 220g, 330g
Advantages
- High resolution, improved chromatographic performance, and reproducibility
- Supports work at higher flow rates
ACCESS Cartridges
Orochem’s new ACCESS empty flash cartridge is an openable column with a twist cap.
Features:
- Suitable for solid and liquid sample loading
- Max pressure: up to 300 psi
- Size range: 4g, 12g, 25g, 40g, 80g, 120g, 220g, 330g
EZYFLASH Bulk Sorbents
- For flash or prep chromatography
- Silica, C18, CN, Phenyl, Phenyl-Hexyl, SAX, SCX, NH2
- Alumina (A, N, B): Irregular, 40-63 µm
- Spherical C18: 40-63 µm, 20-45 µm, 15 µm, and 10 µm
- Spherical C8: 10 µm
Avalon Flash Columns (ISCO Compatible)
Orochem’s Avalon flash columns are Isco compatible. There are both high-pressure (180 psi/12 bar) and low-pressure (45 psi /3bar) flash columns.
Features:
- Clean, pre-packed disposable polypropylene cartridges
- Leak-free guaranteed
- Tight particle size distribution
- Low Fines
- Neutral pH
- Controlled water content
- Good resolution and no tailing
- Better separation
- Higher plate count
- Purification can be carried out at higher flow rates
Specifications
- Particle size 40-60 microns
- Mesh size: 230-400
- Pore Size: 60 Å
Avalexa Flash Columns (Biotage SNAP Compatible)
Optimized for drug discovery and natural product purification with high sample load capacity and reduced solvent usage.
Features:
- Gives the best purification performance
- Tighter bands and narrower peaks for improved fractionation
- Delivers better separation, higher fraction purity and increased sample loads
- More loading capacity
- Less cartridge and solvent usage
- Increased separation efficiency
- Higher fraction purity
- High-performance packing technology
- Greater cartridge consistency
Alexa Flash Columns (Low Pressure, Biotage Compatible)
Orochem’s Alexa flash columns (Biotage Compatible) are rated for low pressure 45psi /3bar. Cartridges are packed with symmetrical sorbent compression to ensure improved separation and reproducibility.
Features:
- Gives best purification performances under low pressure.
- Tighter bands and narrower peaks for improved fractions.
- Delivers better separation, higher fraction purity, and increased sample loads.
- Low Fines
- Neutral pH
- High-performance packing technology.
- Greater cartridge consistency.
Specifications:
- Particle size 40-60 microns
- Mesh size: 230-400
- Pore Size: 60A
Aqua Flash Columns (Jones Flash Master Compatible)
Orochem Aqua flash chromatography is Jones Flash master compatible, which is a rapid form of preparative flash column chromatography based on optimized pre-packed columns through which are pumped with solvent at a high flow rate. They are a simple and economical approach to preparative liquid chromatography.
Features:
- Better and faster Solution
- The capacity of the sample can be doubled.
- Samples can be run at higher flow rates.
- Lower cartridge pressure drop.
Order Flash Chromatography Columns
Shop our full line of flash chromatography columns online, or contact our technical team for phase selection and pricing details.
- Application Note
- Flyer / Documents
Flash Chromatography System
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