Production of Tagatose by Continuous Chromatographic Separation of Lactose Hydrolysate Isomerate :

Hydrolysate Isomerate

Simulated Moving Bed (SMB) chromatography is a continuous purification technique that has higher throughput and requires less solvent than regular batch chromatography. Even for difficult separations, it can achieve high yield and high purity at a reasonable production rate.

Process principle:

SMB is a chromatographic technique based on a flow of liquid moving countercurrent to a constant flow of solid (stationary phase). Countercurrent flow enhances the potential for the separation and, hence, makes the process more efficient. It also allows a continuous flow of feed material to be separated, which improves the throughput of the equipment compared to traditional batch chromatography.


Tagatose separation:

Tagatose is manufactured starting from Milk whey, which is major source of lactose. Lactose is hydrolyzed using enzymatic beads into monosaccharaides, Glucose and Galactose. Unconverted lactose, salts can be separated from sugar mixture using Ion-exchange SMB process. Sugar mixture is then separated using ISOSEP SMB unit consisting Ion exchange resin that efficiently separates high purity Glucose and Galactose as product streams, (95-99 wt. % purity) with high recovery. Glucose stream can be concentrated and commercialized as high purity Glucose syrup whereas Galactose stream is enzymatically/chemically isomerized to Tagatose. TGSEP SMB unit, available from Orochem Technologies Inc., can separate Tagatose at 95-99 wt. % purity and high concentrations as well.

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Title Citation Cutomer Affiliation
Rotary valve apparatus for simulated moving bed separations Oroskar, Anil R. U.S. Patent 8,349,175, issued January 8, 2013. Orochem Technologies, Inc.
Process and adsorbent for separating ethanol and associated oxygenates from a biofermentation system Oroskar, Anil R., Deepak Sharma, David W. House, and Alice M. Havill. U.S. Patent 8,658,845, issued February 25, 2014. Orochem Technologies, Inc.
Purification of montelukast using simulated moving bed A.K. Mandal, K.J. Ranbhan, G.G. Pai, A. Agarwal, R.V. N. Rema, A. Oroskar Orochem Technologies, Inc.
Mannose production from palm kernel meal using simulated moving bed separation Anil R Oroskar, Naveen S Sudharsan, Priyanka Anil Oroskar, Omkar M Kulkarni US Patent 9163050 B2, 2012 Orochem Technologies, Inc.
SMB process for the purification of ethanol and butanediol with integrated regeneration Sharma, Deepak, Rahul K. Keswani, Wahab Mahmood, and Asha A. Oroskar. U.S. Patent 8,704,016, issued April 22, 2014. US Patent 8704016 B2, 2013 Orochem Technologies, Inc.
Recovery of highly pure alpha-tocotrienol from crude palm oil extract Oroskar, Anil, Deepak Sharma, Vanshidhar Singh, Anand Oroskar, and Gautham Oroskar. U.S. Patent 8,937,191, issued January 20, 2015. US Patent 8937191 B2, 2012 Orochem Technologies, Inc.