Description
Orochem Technologies offers a family of polysaccharide-based chiral stationary phases (CSPs) for liquid chromatography under the Epitomize brand name. The CSPs are available in particle sizes from 3 microns up to 300 microns, and columns can be ordered in many different configurations for use in UHPLC, HPLC, prep/semi-preparative LC, and simulated moving bed (SMB) chromatography. The Epitomize family of chiral stationary phases is composed of two series. Epitomize CSP-1 is based on derivatized polysaccharides that are coated onto modified silica gel. Epitomize CSP-2 is based on derivatized polysaccharides that are covalently-bound to silica gel. The best CSP for a given separation depends on several factors. For the racemate, these factors include structure, polarity, and the type and number of functional groups present. Although all of the CSPs are based on polysaccharides, each typically shows a different chiral response for the same racemate. This response can also change dramatically with the selection of mobile phase. Together, these CSPs permit the separation of a very broad range of racemates. Both the CSP-1 and CSP-2 Series can be used in normal phase, polar phase, reverse phase, and SFC. Standard modifiers are TEA, DEA, ethanolamine, TFA, acetic acid, etc. and the use level is typically around 0.1%.
Each column is tested before packaging and a chromatogram with test conditions and column performance data is included.
