Flash Chromatography Systems & Pre-Packed Columns

Flash Columns & Chromatography Systems

Orochem Technologies manufactures high-performance flash chromatography columns and partners with Santai Science to offer the SepaBean™ flash chromatography systems in the United States. Flash chromatography is a rapid, cost-effective form of preparative liquid chromatography that uses optimized pre-packed columns and high flow rates for faster separations. Our polypropylene and stainless steel column designs ensure safe handling, high pressure compatibility, and reproducible results.

flash column chromatography

What is Flash Chromatography?

Flash chromatography is a preparative technique for compound purification, using pre-packed columns and pressurized solvent delivery to achieve quick, efficient separations. Orochem’s symmetrical sorbent compression technology enhances chromatographic performance, delivering sharper peaks, higher resolution, and consistent results.

Orochem Technologies is partnering with Santai Science to offer SepaBean™ machine flash chromatography systems in the Midwest. Santai Science was established in 2004 and focused on developing and providing separation and purification systems.SepaBean™ does more than basic function of separation and purification, the flash chromatography system provides innovative approaches to technology learning and knowledge sharing.
flash chromatography
Model SepaBean™ machine U SepaBean™ machine T SepaBean™ machine SepaBean™ machine 2 SepaBean™ machine 2S SepaBean™ machine L
Flow range (mL/min) 1-100; 1-200 1-200 1-200 1-200 1-300 50-1000
Max. pressure (psi) 100; 200 200 200 500 400 150
Gradients 2 solvents, binary 4 solvents binary with combination of any 2 4 solvents binary 4 solvents binary with 3rdsolvents modifier 4 solvents binary with 3rdsolvents modifier 4 solvents binary with combination of any 2
Sample loading capacity 10 mg – 33g 10 mg – 33g 10 mg – 33g 10 mg – 33g 10 mg – 33g 8g- 300 g
Column sizes 4 -330 g, up to 3 kg with adapters 4 -330 g, up to 3 kg with adapters 4 -330 g, up to 3 kg with adapters 4 -330 g, up to 3 kg with adapters 4 -330 g, up to 3 kg with adapters 800g- 3kg
More Details

EZY FLASH Columns (Luer-Lock Connections)

Pre-packed, leak-free polypropylene cartridges compatible with most flash chromatography systems. Supports high flow rates and offers improved reproducibility.

Features:

  • Pre-packed disposable poly-propylene cartridges
  • Leak Free up to 150 psi
  • Proprietary dry packing procedure
  • Lure-Lock end connections
  • Compatibility with most flash chromatography systems
  • Improved chromatographic performance and reproducibility
  • Liquid sample injection
  • Support work at higher flow rates
  • Biotage SNAP compatible

Specifications

  • Particle size irregular 40-60 microns or spherical 50 microns
  • Mesh size: 230-400
  • Pore Size: 60 Å
  • NP, RP, IX available
  • ize range: 4 – 330 g
EZY FLASH CARTRIDGE DIMENSIONS
Flash cartridge 4 g, MP 200 psi
Flash cartridge 12 g, MP 200 psi
Flash cartridge 25 g, MP 200 psi
Flash cartridge 40 g, MP 200 psi
Flash cartridge 60 g, MP 200 psi
Flash cartridge 80 g, MP 200 psi
Flash cartridge 100 g, MP 150 psi
Flash cartridge 120 g, MP 200 psi
Flash cartridge 220 g, MP 150 psi
Flash cartridge 330 g, MP 150 psi
PHASES</td style="background-color: #d1bedb;"> TYPE</td style="background-color: #d1bedb;"> PARTICLE SIZE [µm]</td style="background-color: #d1bedb;">
Silica</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
N-Alumina</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
A-Alumina</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
B-Alumina</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
C18</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
NH2</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
CN</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
DIOL</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
SCX</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">
SAX</td style="background-color: #d1bedb;"> irregular</td style="background-color: #d1bedb;"> 40-63</td style="background-color: #d1bedb;">
spherical</td style="background-color: #d1bedb;"> 50</td style="background-color: #d1bedb;">

Avalon Flash Columns (ISCO Compatible)

Orochem’s Avalon flash columns are Isco compatible. There are both high pressure ( 180 psi/12 bar) and low pressure (45 psi /3bar) flash columns.

Features:

  • Clean , pre-packed disposable poly-propylene cartridges
  • Leak Free guaranteed
  • Tight particle size distribution
  • Low Fines
  • Neutral pH
  • Controlled water content
  • Good resolution and no tailing
  • Better separation
  • Higher plate count
  • Purification can be carried out at higher flow rates

Specifications

  • Particle size 40-60 microns
  • Mesh size: 230-400
  • Pore Size: 60 Å

Avalexa Flash Columns (Biotage SNAP Compatible)

Optimized for drug discovery and natural product purification with high sample load capacity and reduced solvent usage.

Features:

  • Gives the best purification performance
  • Tighter bands and narrower peaks for improved fractionation
  • Delivers better separation, higher fraction purity and increased sample loads
  • More loading capacity
  • Less cartridge and solvent usage
  • Increased separation efficiency
  • Higher fraction purity
  • High performance packing technology
  • Greater cartridge consistency

Alexa Flash Columns (Low Pressure, Biotage Compatible)

Orochem’s Alexa flash columns (Biotage Compatible)are rated for low pressure 45psi /3bar. Cartridges are packed with symmetrical sorbent compression to ensure improved separation and reproducibility.

Features:

  • Gives best purification performances under low pressure.
  • Tighter bands and narrower peaks for improved fractions.
  • Delivers better separation, higher fraction purity and increased sample loads.
  • Low Fines
  • Neutral Ph
  • High performance packing technology.
  • Greater cartridge consistency.

Specifications:

Particle size 40-60 microns
Mesh size: 230-400
Pore Size: 60A

Aqua Flash Columns (Jones Flash Master Compatible)

Orochem Aqua flash chromatography is Jones Flash master compatible, which is a rapid form of preparative flash column chromatography based on optimized pre-packed columns through which are pumped with solvent at a high flow rate. They are simple and economical approach to preparative liquid chromatography.

Features:

  • Better and faster Solution
  • Capacity of the sample can be doubled.
  • Samples can be run at higher flow rates.
  • Lower cartridge pressure drop.

ISOSPEED Flash Chromatography System

Industrial-scale purification system for kilo-scale compound isolation, available in NP, RP, chiral, and custom bonded phases. The ISOSPEED flash purification system brings together the quality, performance and reproducibility to make it ideal for large scale purifications.

  • Solvent delivery system with flow control
  • Inline sample loading
  • Online-UV detection
  • Cartridge loading and unloading cart
  • N2 environment and leak detection port

Features:

  • Single prep scale flash chromatography system
  • Custom sizes availability based on customer requirements
  • Cheaper than any other competitor brands
  • Available in normal phase (NP), reversed phase (RP), Chiral or any other bonded phase
  • Uses easy to install pre-packed ISOSPEED flash columns
  • Ideal for post-synthesis purification of compounds at kilo scale
  • cGMP and CIP compliant
  • Unique swivel design for easy loading and unloading

Flash Chromatography Phases & Specifications

We offer a complete range of phases for flash chromatography:

  • Silica (irregular or spherical)
  • N-Alumina, A-Alumina, B-Alumina
  • C18, NH2, CN, Diol, SCX, SAX

Particle sizes: 40–63 µm (irregular) or 50 µm (spherical)
Pore sizes: 60 Å
Available in normal phase, reversed phase, ion exchange (IX), and specialty chemistries.

Order Flash Chromatography Columns & Systems

Shop our full line of flash chromatography columns and SepaBean™ systems online, or contact our technical team for system specifications, phase selection, and pricing details.

  • Application Note
  • Flyer / Documents

Flash Chromatography System

Flash Chromatography System

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