Simulated moving bed chromatography

Established in 1996, Orochem is globally recognized as a unique vertically-integrated organization for commercial ton-scale purification of economically viable molecules. Orochem conducts proof of concept leading to pilot scale purification to validate feasibility and viability of commercial scale-up using proprietary chromatographic/ion exchange separation technique involving simulated moving bed (SMB) technology. To date, Orochem has successfully installed pilot scale and commercial scale purification systems at customer’s sites in north America, Europe and Asia, such as protein purification SMB systems of plant proteins, recombinant proteins, and whey proteins; nutraceutical and API purification SMB systems of phospholipids, Omega 3 fatty acids, curcuminoids, and sugars. In addition, Orochem successfully manufactures up to kilo scale purification products of chiral drugs, beta-carotene, tocotrienols , 2,3-butanediol, 1-decene, and anthocyanin.

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