Positive Pressure Processor

Performing vacuum-driven SPE with 96-well format filter plates is a suitable method if all samples are of uniform consistency, however this technique can present some challenges with complex samples such as plasma or other biofluids. These problems are mainly due to the mechanism of attempting to pull a uniform vacuum through all 96 positions.

Positive Pressure Processor is an ideal accessory for solid phase extraction (SPE) applications with the ability to provide set pressure levels for conditioning, sample transfer, wash steps, along with the line pressure for drying prior to the elution step.

The salient features of the units include:

  • Modular rack design, allowing quick interchangeability between 1 ml, 3 ml and 6 ml columns, eluting into 12 x 75 mm, 13 x 100 mm, and 16 x 100 mm test-tube racks respectively.
  • Uniform gas distribution through the manifold ensures uniform pressure and uniform liquid flow at each SPE tube. The uniform flow design ensures uniform flow along with reproducible SPE runs from column to column. It also ensures uniform flow rate when less than 96 columns are used.
  • Liquid flow rate in the columns changes quickly and proportionately when gas pressure is changed. The pressurized air source can be replaced with other inert dry gases like Nitrogen or Argon.

Positive pressure elutions guarantee more reproducible results, higher percentage recoveries and a more consistent flow rate. With the positive pressure system’s optimal and reproducible functioning, extraction conditions for each sample are assured, regardless of the sample viscosity, filter variations or other variable conditions.

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