Polymer based solid phase extraction products

Orochem synthesizes a full range of polymer-based, solid phase extraction (SPE) sorbents. Every sorbent batch must pass a series of quality control tests to ensure batch-to-batch reproducibility and performance. Orochem’s Panthera Deluxe and Agility Deluxe products provide high performance at an affordable price. Sorbents are available in cartridges, 96-well plates, and microelute plate format. Combined method development 96-well plates can be custom made upon request.
Polymer Based

Panthera Deluxe Polymeric SPE Products

The Panthera Deluxe sorbent is based on poly-DVB and provides both hydrophobic and hydrophilic retention. It demonstrates high capacity and retention for a full range of neutral, basic, and acidic compounds and is particularly suitable for pain management drugs and other pharmaceuticals.

Technical Specifications:

  • Mode: Reversed phase
  • Average Particle Size: 15 µm
  • Average Pore Size: 39 Ă…
  • Sorbent Substrate: Polymeric DVB
  • Water Wettable: Yes
  • Mass Spec Compatible: Yes
  • pH Range: 0-14

Panthera Customer Applications

Orochem customers use Panthera to separate the following molecules:

  • Reloxifene
  • Albendazole
  • Topiramate
  • Pregabalin
  • Dolutegravir
  • Dapagliflozine
  • Ibuprofen
  • Loratidine
  • Bile Acids
  • Paliperidon
  • Sofosbeuvir
  • Chlorozoxazone
  • Pramipexole
  • Hydroxychloroquine
  • Isosorbide Mononitrate
  • BUPIVACAINE Liposomal
  • Amphotericine B Liposomal

NEW AGILITY DELUXE POLYMERIC ION-EXCHANGE SPE PRODUCTS

Agility Deluxe poly-DVB-based ion-exchange SPE products are available in four different chemistries: SCX, SAX, WCX, and WAX. These sorbents are ideal for extraction of a wide range of acidic or basic compounds and are particularly suited for pharmaceutical, environmental applications, and peptide analyses.

Agility Deluxe SCX is a mixed mode sorbent that combines strong cation exchange with a reversed phase. It allows neutral and acid compound elution with methanol and basic compound elution with base in an organic solvent. This sorbent targets weakly basic compounds.

Technical Specifications:

  • Mode: Mixed mode, strong cation-exchange and reversed phase
  • Ion Exchange Capacity (Sulfonic acid content): 0.8-1.2 meq/gram
  • Functional Group: SO3-
  • Average Particle Size: 15 µm
  • Average Pore Size: 39 Ă…
  • Sorbent Substrate: Polymeric DVB
  • Water Wettable: Yes
  • Mass Spec Compatible: Yes
  • pH Range: 0-14

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Agility Deluxe WCX is a weak cation exchange sorbent. It allows neutral and acid compound elution with methanol and basic compound elution with base in an organic solvent. It targets basic compounds, including strong base.

Technical Specifications:

  • Mode: Weak cation
  • Functional Group: COO-
  • Average Particle Size: 15 µm
  • Average Pore Size: 39 Ă…
  • Sorbent Substrate: Polymeric DVB
  • Water Wettable: Yes
  • Mass Spec Compatible: Yes
  • pH Range: 0-14

Agility Deluxe SAX is mixed mode sorbent that combines strong anion exchange with a reversed phase. It allows neutral and basic compound elution with methanol and acidic compound elution with acid in an organic solvent. It targets weakly acidic compounds.

Technical Specifications:

  • Mode: Mixed-mode, strong anion exchange and reversed phase
  • Functional Group: Quaternary ammonium
  • Average Particle Size: 15 µm
  • Average Pore Size: 39 Ă…
  • Sorbent Substrate: Polymeric DVB
  • Water Wettable: Yes
  • Mass Spec Compatible: Yes
  • pH Range: 0-14

Agility Deluxe WAXA is weak anion exchange sorbent. It allows neutral and basic compound elution with methanol and acidic compound elution with base in an organic solvent. It targets acidic compounds.

Technical Specifications:

  • Mode: Mixed Mode, weak anion-exchange, reversed phase
  • Functional Group: Amine
  • Particle Size: 15 µm
  • Pore Size: 39 Ă…
  • Sorbent Substrate: Polymer DVB
  • Water Wettable: Yes
  • Mass Spec Compatible: Yes
  • pH Range: 0-14
General Extraction Method

(based on 30 mg/cc cartridge)

Stationary phase: Reversed phase

(Panthera Deluxe )

  • Condition(optional): 1 ml of methanol followed by 1 ml of water
  • Loading step: 0.1-0.5 ml of plasma or other sample
  • Washing step: 1 ml of water followed by 1 ml of 5% methanol (depending on analyte)
  • Elution step: 1 ml of methanol (depending on analyte, other common solvents are acetonitrile, ethanol)
Stationary phases: Strong cation exchange and mixed mode

(Orpheus SCX, C18-SCX, C8-SCX, Agility Deluxe SCX polymer SPE)

  • Pretreatment of sample: dilute the sample with buffer or with acid (for example, add H3PO4 solution, final conc. is about 5%)
  • Condition steps: 1 ml of methanol followed by 1 ml of water or 1% formic acid in water
  • Loading step: 0.1 -1.0 ml of pretreated sample
  • Washing step: 1 ml of 0.1 N HCl . Dry the sorbents for 2-5 minutes
  • Neutral and acidic compounds elution step: 1 ml of methanol
  • Basic compound elution step: 1 ml of 5% NH4OH in methanol (depending on analyte, other common solvents are acetonitrile, ethanol)
Stationary phases: Strong anion exchange and mixed mode

(Orpheus SAX, C18-SAX, C8-SAX, Agility Deluxe SAX polymer SPE)

  • Pretreatment of sample: dilute the sample with buffer or with base (for example, add NH4OH solution, final conc. is about 5%)
  • Condition steps: 1 ml of methanol followed by 1 ml of water or 5% NH4OH in water
  • Loading step: 0.1 -1.0 ml of pretreated sample
  • Washing step: 1 ml of buffer (pH 7) in 5% methanol . Dry the sorbents for 2-5 minutes
  • Neutral and basic compounds elution step: 1 ml of methanol
  • Acidic compound elution step: 1 ml of 5% formic acid in methanol (depending on analyte, other common solvents are acetonitrile, ethanol)
Stationary phases: Weak cation exchange

(Orpheus WCX, Agility Deluxe WCX polymer SPE)

  • Condition steps: 1 ml of methanol followed by 1 ml of water
  • Loading step: 0.1 -1.0 ml of sample
  • Washing step: 1 ml of water or buffer (pH 5) . Dry the sorbents for 2-5 minutes
  • Neutral and acidic compounds elution step: 1 ml of methanol
  • Basic compound elution step: 1 ml of 2% formic acid in methanol (depending on analyte, other common solvents are acetonitrile, ethanol)
Stationary phases: Strong cation exchange and mixed mode

(Orpheus SAX, C18-SAX, C8-SAX, Agility Deluxe SAX polymer SPE)

  • Condition steps: 1 ml of methanol followed by 1 ml of water
  • Loading step: 0.1 -1.0 ml of sample
  • Washing step: 1 ml of buffer (pH 4). Dry the sorbents for 2-5 minutes
  • Neutral and basic compounds elution step: 1 ml of methanol
  • Acidic compound elution step: 1 ml of 5% NH4OH in methanol (depending on analyte, other common solvents are acetonitrile, ethanol)

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