Montelukast is a leukotriene receptor antagonist and an inhibitor of leukotriene biosynthesis. Montelukast sodium is used in the treatment of asthma.

Orochem Technologies Inc developed a continuous SMB process for the purification of a crude Montelukast sodium mixture comprising Montelukast sodium-trans, impurities, an organic solvent, and water. The final montelukast sodium-trans product has a montelukast purity of at least 99.5 wt-%.

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